Publications

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Selected Publications

Mehta KPM, Thada V, Zhao R., Krishnamoorthy A., Leser M., Lindsey Rose K., Cortez D. CHK1 phosphorylates PRIMPOL to promote replication stress tolerance. Science Advances. 2022 Apr;8(13):eabm0314. doi: 10.1126/sciadv.abm0314

Ravenstein SX, Mehta KPM, Kavlashvili T, Byl Jo Ann, Zhao R, Osheroff N, Cortez D, Dewar JM. Topoisomerase II poisons inhibit vertebrate DNA replication through distinct mechanisms. EMBO. 2022 Jun 14;41(12):e110632. doi: 10.15252/embj.2022110632

Mehta KPM, Laimins LA. High-Risk Human Papillomaviruses and DNA Repair. Recent Results Cancer Res. 2021;217:141-155. doi: 10.1007/978-3-030-57362-1_7

Mehta KPM, Lovejoy CA, Zhao R, Heintzman DR, Cortez DK. HMCES Maintains Replication Fork Progression and Prevents Double-Strand Breaks in Response to APOBEC Deamination and Abasic Site Formation. Cell Reports, 2020. doi: 10.1016/j.celrep.2020.107705

Dollins DE, Bai W, Fridy PC, Otto JC, Neubauer JL, Gattis SG, Mehta KPM, and York JD. Vip1 is a kinase and pyrophosphatase switch that regulates inositol diphosphate signaling. PNAS, 2020. doi: /10.1073/pnas.1908875117

Mohni KN, Wessel SR, Zhao R, Wojciechowsk AC, Luzwick JW, Layden H, Eichman BF, Thompson PS, Mehta KPM, and Cortez D. HMCES maintains genome integrity by shielding abasic sites in single strand DNA. Cell, 2018. doi: 10.1016/j.cell.2018.10.055

Mehta K, Laimins L. Human papillomaviruses preferentially recruit DNA repair factors to viral genomes for rapid repair and amplification. mBio, 2018. doi: 10.1128/mBio.00064-18.

Mehta KP *, Gunasekharan VK *, Satsuka A, Laimins L.Human papillomaviruses activate and recruit SMC1 cohesin proteins for the differentiation-dependent life cycle through association with CTCF insulators. PLoS Pathogens, 2015. doi: 10.1371/journal.ppat.1004763

Satsuka A, Mehta KP, Laimins L. p38MAPK and MK2 Pathways Are Important for the Differentiation-Dependent Human Papillomavirus Life Cycle. J Virol. 2015 Feb;89(3):1919-24. doi: 10.1128/JVI.02712-14. Epub 2014 Nov 19.

Kotnik Halavaty K, Regan J, Mehta KP, Laimins L. Human papillomavirus E5 oncoproteins bind the A4 endoplasmic reticulum protein to regulate proliferative ability upon differentiation. Virology. 2014 Mar;452-453:223-30. doi: 10.1016/j.virol.2014.01.013

Gillespie KA, Mehta KP, Laimins LA, Moody CA. Human papillomaviruses recruit cellular DNA repair and homologous recombination factors to viral replication centers. J Virol. 2012 Sep;86(17):9520-6. doi: 10.1128/JVI.00247-12

Bodily JM, Mehta KP, and Laimins L. Human Papillomavirus E7 Enhances Hypoxia-Inducible Factor 1 Mediated Transcription By Inhibiting Binding Of Histone Deacetylases Cancer Research 2011. 71:1187-95

Bodily JM, Mehta KP and Laimins L. The E7 Open Reading Frame Acts in Cis and Trans to Mediate Differentiation-Dependent Activities in the Human Papillomavirus Type 16 Life Cycle. J. Virol. 2011;85 8852-8862

Hong S, Mehta KP, and Laimins L. Suppression of STAT-1 Expression by Human Papillomaviruses Is Necessary for Differentiation-Dependent Genome Amplification and Plasmid Maintenance Journal of Virology, Sep 2011; 85: 9486 – 9494.

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